Cirurgia conservadora da mama versus mastectomia radical nos resultados oncológicos de múltiplos Cânceres de Mama Ipsilaterais

Authors

  • Daniel Garcia Pimenta
  • Rafaela Melo Macedo
  • Fernanda Folgosi
  • Pollyana Ferreira Dias
  • Pedro Paulo Moura Ferro Filho
  • André Fleury Cunha Passaglia
  • Rodrigo Luz Santome de Faria
  • Jalsi Tacon Arruda

DOI:

https://doi.org/10.54022/shsv4n4-010

Keywords:

Câncer de Mama, cirurgia conservadora de mama, mastectomia, tumores multifocais, tumores multicêntricos, recorrência local, sobrevivência

Abstract

A eficácia clínica do tratamento de câncer de mama ipsilateral multifocal (MF) e multicêntrico (MC) usando terapia conservadora da mama (TCM) em comparação com o padrão de mastectomia ainda é incerta. As controvérsias referem-se à recorrência locorregional e a sobrevida livre de doença. Esta revisão compara os resultados clínicos após TCM versus mastectomia para cânceres MF e MC, definidos coletivamente como múltiplos cânceres de mama ipsilaterais. Para isso, pesquisas eletrônicas abrangentes foram realizadas para identificar artigos completos publicados em inglês entre outubro de 2002 a junho de 2023, comparando principalmente os resultados clínicos da TCM e da mastectomia para cânceres de mama múltiplos ipsilaterais síncronos. Todos os tipos de estudo foram incluídos e os estudos selecionados foram avaliados criticamente, seguindo o protocolo PRISMA para métodos de revisão e relatórios. Os estudos analisados apresentavam qualidade moderada, e históricos com acompanhamento limitado e seleção de casos, favorecendo a TCM em vez da mastectomia para pacientes de baixo risco. A cirurgia conservadora da mama apresenta-se como uma opção viável e segura para pacientes com câncer de mama múltiplo ipsilateral com características selecionadas dos tumores.

References

ARTHUR, Douglas W. et al. Effectiveness of breast-conserving surgery and 3-dimensional conformal partial breast reirradiation for recurrence of breast cancer in the ipsilateral breast: the NRG oncology/RTOG 1014 phase 2 clinical trial. JAMA oncology, v. 6, n. 1, p. 75-82, 2020. Disponível em: https://jamanetwork.com/journals/jamaoncology/article-abstract/2755430

ASSOCIATION OF BREAST SURGERY. Oncoplastic Breast Reconstruction Guidelines for Best Practice, 2014.

BALIC, Marija et al. St. Gallen/Vienna 2023: Optimization of Treatment for Patients with Primary Breast Cancer–A Brief Summary of the Consensus Discussion. Breast Care, v. 18, n. 3, p. 213-222, 2023. Disponível em: https://karger.com/brc/article/18/3/213/836657

BENDIFALLAH, Sofiane et al. Multiple synchronous (multifocal and multicentric) breast cancer: clinical implications. Surgical oncology, v. 19, n. 4, p. e115-e123, 2010. Disponível em: https://pubmed.ncbi.nlm.nih.gov/20615686/

BOUGHEY, Judy C. et al. Local recurrence after breast-conserving therapy in patients with multiple ipsilateral breast cancer: results from ACOSOG Z11102 (Alliance). Journal of Clinical Oncology, v. 41, n. 17, p. 3184-3193, 2023. Disponível em: https://ascopubs.org/doi/abs/10.1200/JCO.22.02553

CLOUGH, Krishna B. et al. Improving breast cancer surgery: a classification and quadrant per quadrant atlas for oncoplastic surgery. Annals of surgical oncology, v. 17, p. 1375-1391, 2010. Disponível em: https://pubmed.ncbi.nlm.nih.gov/20140531/

CLOUGH, Krishna B. et al. Positive margins after oncoplastic surgery for breast cancer. Annals of surgical oncology, v. 22, p. 4247-4253, 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25893409/

CURIGLIANO, Giuseppe et al. De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017. Annals of Oncology, v. 28, n. 8, p. 1700-1712, 2017. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28838210/

HOUVENAEGHEL, Gilles et al. Is breast conservative surgery a reasonable option in multifocal or multicentric tumors?. World Journal of Clinical Oncology, v. 7, n. 2, p. 234, 2016. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826969/

LIM, Woosung et al. Breast conserving surgery for multifocal breast cancer. Annals of surgery, v. 249, n. 1, p. 87-90, 2009. Disponível em: https://pubmed.ncbi.nlm.nih.gov/19106681/

LYNCH, Siobhan P. et al. Breast cancer multifocality and multicentricity and locoregional recurrence. The oncologist, v. 18, n. 11, p. 1167-1173, 2013. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24136008/

MOHER, David et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of internal medicine, v. 151, n. 4, p. 264-269, 2009. Disponível em: https://pubmed.ncbi.nlm.nih.gov/19622511/

NERI, Alessandro et al. Clinical significance of multifocal and multicentric breast cancers and choice of surgical treatment: a retrospective study on a series of 1158 cases. BMC surgery, v. 15, n. 1, p. 1-10, 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25586679/

PATANI, Neill; CARPENTER, Robert. Oncological and aesthetic considerations of conservational surgery for multifocal/multicentric breast cancer. The Breast Journal, v. 16, n. 3, p. 222-232, 2010. Disponível em: https://pubmed.ncbi.nlm.nih.gov/20565467/

QIU, Han et al. Effect of breast-conserving surgery and modified radical mastectomy on operation index, symptom checklist-90 score and prognosis in patients with early breast cancer. Medicine, v. 99, n. 11, 2020. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220131/

ROSENKRANZ, Kari M. et al. The feasibility of breast-conserving surgery for multiple ipsilateral breast cancer: an initial report from ACOSOG Z11102 (Alliance) trial. Annals of surgical oncology, v. 25, p. 2858-2866, 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34634438/

SCHWARTZ, Gordon F. et al. Proceedings of the consensus conference on breast conservation, April 28 to May 1, 2005, Milan, Italy. Cancer, v. 107, n. 2, p. 242-250, 2006. Disponível em: https://pubmed.ncbi.nlm.nih.gov/16770785/

TAN, Mona P.; SITOH, Nadya Y.; SITOH, Yih Yiow. Optimising breast conservation treatment for multifocal and multicentric breast cancer: a worthwhile endeavour?. World journal of surgery, v. 40, p. 315-322, 2016. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26560151/

VERONESI, Umberto et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. New England Journal of Medicine, v. 347, n. 16, p. 1227-1232, 2002. Disponível em: https://pubmed.ncbi.nlm.nih.gov/12393819/

WINTERS, Zoe Ellen; BERNAUDO, Lorenzo. Evaluating the current evidence to support therapeutic mammoplasty or breast-conserving surgery as an alternative to mastectomy in the treatment of multifocal and multicentric breast cancers. Gland Surgery, v. 7, n. 6, p. 525, 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30687626/

WINTERS, Zoe E.; BENSON, John R. Surgical treatment of multiple ipsilateral breast cancers. Journal of British Surgery, v. 105, n. 5, p. 466-468, 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29412447/

WINTERS, Zoe E. et al. Systematic review of the impact of breast-conserving surgery on cancer outcomes of multiple ipsilateral breast cancers. Bjs Open, v. 2, n. 4, p. 162-174, 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30079385/

YERUSHALMI, R. et al. Is breast-conserving therapy a safe option for patients with tumor multicentricity and multifocality?. Annals of oncology, v. 23, n. 4, p. 876-881, 2012. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21810730/

Published

2023-11-09

How to Cite

Pimenta, D. G., Macedo, R. M., Folgosi, F., Dias , P. F., Ferro Filho , P. P. M., Passaglia , A. F. C., de Faria , R. L. S., & Arruda, J. T. (2023). Cirurgia conservadora da mama versus mastectomia radical nos resultados oncológicos de múltiplos Cânceres de Mama Ipsilaterais. STUDIES IN HEALTH SCIENCES, 4(4), 1235–1248. https://doi.org/10.54022/shsv4n4-010

Most read articles by the same author(s)