Epidemiological study of antibiotic-resistant Helicobacter pylori in Brazil a meta-analysis


  • Ana Carolina Messias de Souza Ferreira da Costa
  • Amina Kadja Martins Cahú
  • Amanda Reges de Sena
  • Allana Fernanda de Araújo Barroso Leite
  • Tonny Cley Campos Leite
  • Isis Filgueira Sampaio
  • Maria Clara Lorrete Laviola
  • Bruno Cavalcante Linhares
  • Camilla Thays Melquiades Tavares de Oliveira
  • José Vinicius Perminio Barbosa
  • Daniela Simões Velame




Antibiotic Resistance, Epidemiology, Clarithromycin, Prevalence, Brazil


Objectives: To evaluate the proportion of Helicobacter pylori resistant to tetracyclines, amoxicilline, furazolidone, clarithromycin, fluoroquinolones and amoxicillin in Brazil and to present genotypic characteristics of strains. Methodology: Search in PubMed, SciELO, VHL and Medline. Twelve Brazilian studies on resistant Helicobacter pylori were selected, with a total of 2,038 patients. The options were performed with a confidence interval of 95% and an alpha of 0.05 using the software RStudio5.0. Results: low resistance rate for 04 antibiotics, being lower than the 15% threshold considered for empirical treatment. However, for metronidazole the rate of 43% and clarithromycin 16% macrolide and amoxicillin increased resistance when compared to previous years. The Southeast region had the highest rates. A clarithromycin ae A2147 in the 23s 23s RNA gene was the most prevalent conferring clear resistance. Conclusion: The increase in resistance to clarithromycin and amoxicillin resistance demonstrates that the factors that still increase for the acquisition of resistance still exist. Therefore, constant epidemiological surveillance is necessary so that we are aware of the resistance profile, performing assertive therapy.


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How to Cite

Costa , A. C. M. de S. F. da, Cahú, A. K. M., Sena, A. R. de, Leite, A. F. de A. B., Leite, T. C. C., Sampaio, I. F., Laviola, M. C. L., Linhares, B. C., Oliveira, C. T. M. T. de, Barbosa, J. V. P., & Velame, D. S. (2024). Epidemiological study of antibiotic-resistant Helicobacter pylori in Brazil a meta-analysis. Caderno Pedagógico, 21(5), e4568. https://doi.org/10.54033/cadpedv21n5-210